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Autoradiographic analysis of the proliferation in vitro of six murine cell lines of non-malignant or malignant origin

✍ Scribed by W. Sawicki; J. Kieler; P. Briand

Publisher
John Wiley and Sons
Year
1967
Tongue
French
Weight
606 KB
Volume
2
Category
Article
ISSN
0020-7136

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✦ Synopsis

A high rate of Celt growth in cutture has often been thought to be indicative of malignancy. In the present work the generation time of six murine cell lines and the duration of their various mitotic and intermitotic phases were studied using thymidine-~i-~H and autoradiography. No definite covrelation could be established between the growth kinetics and the tumor-producing capacity of these cells, but cultures which were more than one year old showed a slightly shorter generation time and a somewhat shorter phase of D N A synthesis ( t s ) than 6to 8-month-old cultures.

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