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Autophagy and Liver Disease

โœ Scribed by Puri, Pankaj

Book ID
123164764
Publisher
Elsevier
Year
2013
Tongue
English
Weight
121 KB
Volume
3
Category
Article
ISSN
0973-6883

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In the classical form of alpha1-antitrypsin (AT) deficiency, a point mutation in AT alters the folding of a liver-derived secretory glycoprotein and renders it aggregation-prone. In addition to decreased serum concentrations of AT, the disorder is characterized by accumulation of the mutant alpha1-a