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Autonomous Fueled Mechanical Replication of Nucleic Acid Templates for the Amplified Optical Detection of DNA

✍ Scribed by Yossi Weizmann; Zoya Cheglakov; Valeri Pavlov; Itamar Willner

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 558 KB
Volume: 45
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200503810

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**A catalytic cutter** for the sensitive detection of a target DNA, a Tay–Sachs disorder mutant, is described by I. Willner and co‐workers in their Communication on page 2238 ff. As the cover picture shows, a tailored nucleic acid hairpin probe (top) is opened upon hybridization with the analyte DNA