Automation of toxicological screenings on a Hewlett Packard Chemstation GC-MS system
✍ Scribed by Tom Fiers; Viviane Maes; Claude Sevens
- Book ID
- 103042216
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 481 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0009-9120
No coin nor oath required. For personal study only.
✦ Synopsis
Objectives: To optimize the interpretation of GC-MS toxicological screenings (i.e., to facilitate ion specific queries, create custom reports specifically adapted to each confirmation procedure, and eliminate redundant and/or inaccurate data on library search reports).
Design and Methods:
The MS Chemstation software of the Hewlett Packard 5972 is constructed in a modular way. We made extensive modifications to two modules, the data analysis and the report modules, using the built-in MS Chemstation macro language.
Results: Ion specific queries were automated for over 60 commonly encountered analytes. Custom reports were created for the confirmation of positive drugs-of-abuse immunoassay results. With the incorporation of decision support rules into the data processing and the reporting phases, we obtained sensitive, accurate, and concise reports.
Conclusions:
The MS Chemstation software can be tailored to the needs of each individual application. The incorporation of a rulebased decision support system enhances the quality of the GC-MS toxicological screenings and results in faster, easier, and more reliable processing.