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Automated system for on-line desorption of dried blood spots applied to LC/MS/MS pharmacokinetic study of flurbiprofen and its metabolite

✍ Scribed by Julien Déglon; Aurélien Thomas; Youssef Daali; Estelle Lauer; Caroline Samer; Jules Desmeules; Pierre Dayer; Patrice Mangin; Christian Staub


Book ID
108189828
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
678 KB
Volume
54
Category
Article
ISSN
0731-7085

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On-line desorption of dried blood spots
✍ Aurélien Thomas; Julien Déglon; Thierry Steimer; Patrice Mangin; Youssef Daali; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 267 KB

## Abstract An assay for the simultaneous analysis of pharmaceutical compounds and their metabolites from micro‐whole blood samples (__i.e__. 5 μL) was developed using an on‐line dried blood spot (on‐line DBS) device coupled with hydrophilic interaction/reversed‐phase (HILIC/RP) LC/MS/MS. Filter pa