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Automated large-scale purification of a G protein-coupled receptor for neurotensin

โœ Scribed by Jim F White; Loc B Trinh; Joseph Shiloach; Reinhard Grisshammer


Book ID
117106348
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
217 KB
Volume
564
Category
Article
ISSN
0014-5793

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Generation of RNA Aptamers to the G-Prot
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G-protein-coupled receptors (GPCRs) are integral membrane proteins involved in signal transduction and constitute major drug targets for disease therapy. Aptamers, which are globular RNA or DNA molecules evolved to specifically bind a target, could represent a valuable tool with which to probe the r