Automated high-pressure liquid chromatographic analysis of aspirin, phenacetin, and caffeine

✍ Scribed by Peter P. Ascione; George P. Chrekian

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 412 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600640633

✦ Synopsis

An automated high-pressure liquid chromatographic (HPLC) method for the separation and determination of aspirin, phenacetin, and caffeine in pharmaceutical dosage forms is described. Separation of these compounds for quantitation is achieved on a controlled pore glass support, utilizing a mixture of acetic acid and chloroform as the mobile phase. The method is specific, accurate, and simple and provides for the quantitation of each chromatogram in a continuous fashion every 7 min. HPLC separation of other analgesics was studied on a spherical siliceous support. The feasibility of determining free salicylic acid in analgesics also was established.

Keyphrases Aspirin, phenacetin, and caffeine-automated high-pressure liquid chromatographic analysis 0 Phenacetin, aspirin, and caffeine-automated high-pressure liquid chromatographic analysis 0 Caffeine, aspirin, and phenacetin-automated highpressure liquid chromatographic analysis 0 High-pressure liquid chromatography-automated analysis, aspirin, phenacetin, and caffeine