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Autologous fibrin glue in peripheral nerve regeneration in vivo

✍ Scribed by Byung-Ho Choi; Sang-Gyun Han; Sung-Hoon Kim; Shi-Jiang Zhu; Jin-Young Huh; Jae-Hyung Jung; Seoung-Ho Lee; Byung-Yong Kim

Book ID
102513644
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
392 KB
Volume
25
Category
Article
ISSN
0738-1085

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✦ Synopsis

The activity of several growth factors on peripheral nerve regeneration is reported. Autologous fibrin glue contains a large number of platelets, which release significant quantities of growth factors. In order to understand the role of autologous fibrin glue in peripheral nerve regeneration, a 15-mm rabbit peroneal nerve defect was repaired using a vein graft filled with autologous fibrin glue. Axonal regeneration was examined using histological and electrophysiological methods. The extent of axonal regeneration was superior when treated with autologous fibrin glue. Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in autologous fibrin glue, might effectively promote peripheral nerve regeneration in nerve defects.

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