Autoimmunity to RNA polymerase II is focused at the carboxyl terminal domain of the large subunit

Phosphorylation of the carboxy-terminal

Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription

✍ Maha M. Gebara; Michael H. Sayre; Jeffrey L. Corden 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 2 views

Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom