Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti-human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis

✍ Scribed by Majida Bouanani; Regis Bataille; Martine Piechaczyk; Sharon Lynn Salhi; Bernard Pau; Madeleine Bastide

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 736 KB
• Volume: 34
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780341218

✦ Synopsis

We evaluated the epitopic specificity pattern of anti-human thyroglobulin (anti-hTg) autoantibodies from patients with primary Sjogren's syndrome (SS). All of the primary SS sera tested contained both IgC and IgM anti-hTg autoantibodies recognizing at least 1 region on hTg; in 65% of the cases, 3 or more regions were recognized. A strong recognition of region 11, as is seen in Hashimoto's thyroiditis, was associated with thyroid disorder in primary SS. These results emphasize the importance of region I1 in autoimmune thyroid disease.

Autoantibodies against human thyroglobulin (hTg) are present in the sera of healthy individuals (1) and of patients with organ-specific disorders such as Hashimoto's thyroiditis (HT) (2) or with systemic autoimmune diseases such as primary Sjogren's syndrome (SS) (3). In an earlier report, we described the production and characterization of 15 anti-hTg mono-From the Unite de Recherche en Immunologie, FacultC de Pharmacie, Cedex, and the Service d'Immunorhumatologie et IN-SERM U 291, Centre Gui-de-Chauliac, Hbpital Saint-Eloi, Montpellier, France.