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Autoimmune-thrombocytopenia and sle in a patient with 5q-anomaly and deletion of the c-fms oncogene

✍ Scribed by Dr. Ulrich Jaeger; Simon Panzer; Claus Bartram; Oskar Haas; Beatrix Volc-Platzer; Wolfgang Graninger; Klaus Geissler; Thaddaeusz Radaszkiewicz; Klaus Lechner

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 218 KB
Volume: 45
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830450112

No coin nor oath required. For personal study only.

✦ Synopsis

Autoimmune-thrombocytopenia was the striking feature in a patient with typical clinical symptoms of systemic lupus erythematosus (SLE), complement C4 deficiency, and positive lupus serology. However, myelodysplasia was found in the bone marrow and chromosome analysis revealed a deletion of the long arm of chromosome 5 (5q-anomaly), which was confirmed by a hemitygosity for the c-fms oncogene (CSF-1-receptor) on Southern blot. Autoimmune phenomena reported In conjunction with myelodysplastic syndromes (MDS), e.g., an elevation of antinuclear antibodies, are usually regarded as nonspecific. This case report suggests that SLE can occur in patients with MDS and that a concomitant autoimmune-thrombocytopenia may mask the typical signs of the Sq-syndrome.

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