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Autoimmune neutropenia following peripheral blood stem cell transplantation

✍ Scribed by Dr. Thomas R. Klumpp; Jay H. Herman; John S. Macdonald; Maryann K. Schnell; Mark Mullaney; Kenneth F. Mangan

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 317 KB
Volume: 41
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830410313

No coin nor oath required. For personal study only.

✦ Synopsis

The differential diagnosis of unexpected neutropenia following bone marrow transplantation includes several potentially life-threatening complications including graft rejection, overwhelming infection, relapse of the underlying neoplasm, and intrinsic graft failure. However, a number of recent reports document that the differential diagnosis also includes autoimmune neutropenia, which, although potentially life-threatening, often responds well to corticosteroids or splenectomy. Autoimmune neutropenia has been reported following both autologous and allogeneic bone marrow transplantation. Herein we report a 31-year-old woman who developed a rapidly falling neutrophil count 11 days following peripheral blood stem cell transplantation for non-Hodgkin's lymphoma. A laboratory evaluation supported a diagnosis of autoimmune neutropenia, and the neutropenia resolved following treatment with steroids and granulocyte-colony stimulating factor. o 1992 Wiiey-Liss, Inc.

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