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Autografting with Ph-negative progenitors in patients at diagnosis of chronic myeloid leukemia induces a prolonged prevalence of Ph-negative hemopoiesis

✍ Scribed by Marina Podestà; Giovanna Piaggio; Mario Sessarego; Anna Pitto; Osvaldo Figari; Monica Soracco; Angelo M. Carella; Anna Dejana; Vittorio Rosti; Giuseppina Fugazza; Giovanbattista Ravera; Enrica Lerma; Mario Cazzola; Andrea Bacigalupo; Francesco Frassoni


Book ID
114217450
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
53 KB
Volume
28
Category
Article
ISSN
0301-472X

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## Abstract Leukemic cells from two patients with Philadelphia‐negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M‐BCR region and formation of __BCR‐ABL__ fusion mRNA with b2a2