Autocrine transforming growth factor-β regulation of hematopoiesis: many outcomes that depend on the context

Density-dependent inhibitory effect of t

Density-dependent inhibitory effect of transforming growth factor-β on human fibroblasts involves the down-regulation of platelet-derived growth factor α-receptors

✍ Y. Paulsson; C. Karlsson; C.-H. Heldin; B. Westermark 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 812 KB

## Abstract We have previously found that transforming growth factor‐β1 (TGF‐β1) inhibits the mitogenic activity of platelet‐derived growth factor (PDGF) in cultures of human neonatal fibroblasts in a density‐dependent fashion. In the present investigation we determined the effect of TGF‐β1 on the