Serially transplantable rat mammary tumor (RMT) cells are not dependent on exogenous epidermal growth factor (EGF) and insulin-like growth factor-I for continuous growth in serum-free medium. Previously, we found that conditioned medium obtained from these cells contained EGF-like mitogenic activity
โฆ LIBER โฆ
Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells
โ Scribed by Venkateswarlu, Srinivas; Dawson, Dawn M; Clair, Patricia St; Gupta, Anjana; Willson, James KV; Brattain, Michael G
- Book ID
- 110066239
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 319 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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Autocrine transforming growth factor a (TGFa) activity and control mechanisms for its expression were examined in a representative clonal isolate (CBS4) of a well-differentiated human colon carcinoma cell line designated CBS. CBS4 cells expressed TGFa and its receptor, epidermal growth factor recept