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Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

✍ Scribed by Kawano, Michio; Hirano, Toshio; Matsuda, Tadashi; Taga, Tetsuya; Horii, Yasuhiro; Iwato, Koji; Asaoku, Hideki; Tang, Bo; Tanabe, Osamu; Tanaka, Hideo


Book ID
109752407
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
322 KB
Volume
332
Category
Article
ISSN
0028-0836

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The evolutionarily conserved Ras/Raf/MEK/ERK pathway is thought to be essential for proliferation of eukaryotic cells. The human multiple myeloma (MM) cell line 8226 encodes an activated K-ras allele and proliferates without requirement for the main MM growth and survival factor IL-6. Surprisingly,