𝔖 Bobbio Scriptorium
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AUTOCRINE AND PARACRINE REGULATION BY CYTOKINES AND GROWTH FACTORS IN MELANOMA

✍ Scribed by Eszter Lázár-Molnár; Hargita Hegyesi; Sára Tóth; András Falus


Book ID
115596442
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
127 KB
Volume
12
Category
Article
ISSN
1043-4666

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## Abstract Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)‐6 is a key factor by driving tumor progression from benign to malignant, invasive tumors in the HaCaT‐model of human skin carcinoma. IL‐6 activates STAT3 and directly stimulates