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Autocrine and paracrine growth regulation of breast cancer: Clinical implications

✍ Scribed by C. Kent Osborne; Carlos L. Arteaga


Publisher
Springer US
Year
1990
Tongue
English
Weight
775 KB
Volume
15
Category
Article
ISSN
0167-6806

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## Abstract Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)‐6 is a key factor by driving tumor progression from benign to malignant, invasive tumors in the HaCaT‐model of human skin carcinoma. IL‐6 activates STAT3 and directly stimulates