## Abstract ## Objective Fibroblasts play a crucial role in the development of systemic sclerosis (SSc), and antifibroblast antibodies (AFAs) capable of inducing a proinflammatory phenotype in fibroblasts have been detected in the sera of SSc patients. This study examined the prevalence of AFAs in
Autoantibody-mediated regulation of B cell responses by functional anti-CD22 autoantibodies in patients with systemic sclerosis
β Scribed by M. Odaka; M. Hasegawa; Y. Hamaguchi; N. Ishiura; S. Kumada; T. Matsushita; K. Komura; S. Sato; K. Takehara; M. Fujimoto
- Book ID
- 108701140
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 293 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0009-9104
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## Objective: This study addresses the hypothesis that a profibrotic pattern of cytokines is produced in the lungs of patients with systemic sclerosis (ssc) and causes fibrosis. ## Methods: Using a reverse transcriptase-polymerase chain reaction technique, interleukin-4 (il-4), il-5, and interfer