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Autoantibodies to tyrosinase : The bridge between melanoma and vitiligo

✍ Scribed by Pnina Fishman; Ofer Merimski; Ehud Baharav; Yehuda Shoenfeld

Book ID
101230164
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
77 KB
Volume
79
Category
Article
ISSN
0008-543X

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✦ Synopsis

defined as an autoantigen in these conditions. In some patients with melanoma the disease is associated with the appearance of ''vitiligo-like'' white patches on

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Vitiligo is a skin disorder characterized by depigmented macules secondary to melanocyte loss. An unusual facet is its relation to melanoma: Cytotoxic T lymphocytes directed to melanocyte antigens are found in both conditions and imply a breakdown of tolerance, yet the resulting immune reaction is t