𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes

✍ Scribed by John C. Lawrence; Joseph Larner; C. Ronald Kahn; Jesse Roth

Publisher
Springer
Year
1978
Tongue
English
Weight
421 KB
Volume
22
Category
Article
ISSN
0300-8177

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✦ Synopsis

Autoantibodies to the insulin receptor mimic the effects of insulin on glycogen synthase and phosphorylase. The interaction of antibodies with adipocyte cell surface insulin receptors seems sufficient to promote stable changes in the activities of these intracellular enzymes, suggesting that internalization or processing of insulin is not important in the generation of these biological responses.

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