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Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy

โœ Scribed by Dr. R. Nemni; S. Braghi; M. G. Natali-Sora; V. Lampasona; E. Bonifacio; G. Comi; N. Canal

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
344 KB
Volume
36
Category
Article
ISSN
0364-5134

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โœฆ Synopsis

We report the presence of serum autoantibodies directed against glutamic acid decarboxylase in a patient with epilepsy and palatal myoclonus not associated with brain lesions. Glutamic acid decarboxylase antibody reactivity was dependent on the presence of carboxy-terminal amino acids, similar to that reported in patients with stiff-man syndrome. Marked reduction in the frequency of epileptic attacks and improvement in palatal myoclonus occurred when benzodiazepine was administered and phenytoin was gradually tapered. Testing for antiglutamic acid decarboxylase antibodies may be indicated in patients with palatal myoclonus and with convulsive disorders refractory to therapy.

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