Autoantibodies in Type 1 and Type 2 diabetes in the Old Order Amish of Lancaster County, Pennsylvania
โ Scribed by J. Miura; T. I. Pollin; Y. Hu; S.-I. Harashima; A. L. Notkins; A. R. Shuldiner
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 97 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0012-186X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Objectives (a) To study whether there was an increased prevalence of glucose intolerance in the parents of probands with Type 1 diabetes and (b) to look for any possible link between the glucose intolerance in the parents with HLA-DQB1 alleles transmitted in excess to the Type 1 diabetes offspring.
The prodromal phase of type 1 diabetes is characterised by the appearance of multiple islet-cell related autoantibodies (Aab). The major target antigens are islet-cell antigen, glutamic acid decarboxylase (GAD), protein-tyrosine phosphatase-2 (IA-2) and insulin. Insulin autoantibodies (IAA), in cont