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Autoantibodies in Type 1 and Type 2 diabetes in the Old Order Amish of Lancaster County, Pennsylvania

โœ Scribed by J. Miura; T. I. Pollin; Y. Hu; S.-I. Harashima; A. L. Notkins; A. R. Shuldiner


Publisher
Springer
Year
2003
Tongue
English
Weight
97 KB
Volume
46
Category
Article
ISSN
0012-186X

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๐Ÿ“œ SIMILAR VOLUMES


Type 1 diabetes in the offspring does no
โœ A. Ramachandran; C. Snehalatha; E. Tuomilehto-Wolf; G. Vidgren; B.W. Ogunkolade; ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 73 KB ๐Ÿ‘ 1 views

Objectives (a) To study whether there was an increased prevalence of glucose intolerance in the parents of probands with Type 1 diabetes and (b) to look for any possible link between the glucose intolerance in the parents with HLA-DQB1 alleles transmitted in excess to the Type 1 diabetes offspring.

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The prodromal phase of type 1 diabetes is characterised by the appearance of multiple islet-cell related autoantibodies (Aab). The major target antigens are islet-cell antigen, glutamic acid decarboxylase (GAD), protein-tyrosine phosphatase-2 (IA-2) and insulin. Insulin autoantibodies (IAA), in cont