Keratin variants are overrepresented in
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Bihui Zhong; Pavel Strnad; Carlo Selmi; Pietro Invernizzi; Guo-Zhong Tao; Angela
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Article
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2009
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John Wiley and Sons
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English
⚖ 890 KB
Keratins (K) 8 and 18 variants predispose carriers to the development of end-stage liver disease and patients with chronic hepatitis C to disease progression. Hepatocytes express K8/K18, whereas biliary epithelia express K8/K18/K19. K8-null mice, which are predisposed to liver injury, spontaneously