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Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis

✍ Scribed by Pietro Invernizzi; Mauro Podda; Pier Maria Battezzati; Andrea Crosignani; Massimo Zuin; Eva Hitchman; Marco Maggioni; Pier Luigi Meroni; Edward Penner; Józefa Wesierska-Gadek


Book ID
119525463
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
271 KB
Volume
34
Category
Article
ISSN
0168-8278

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Keratin variants are overrepresented in
✍ Bihui Zhong; Pavel Strnad; Carlo Selmi; Pietro Invernizzi; Guo-Zhong Tao; Angela 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 890 KB

Keratins (K) 8 and 18 variants predispose carriers to the development of end-stage liver disease and patients with chronic hepatitis C to disease progression. Hepatocytes express K8/K18, whereas biliary epithelia express K8/K18/K19. K8-null mice, which are predisposed to liver injury, spontaneously