Autoantibodies Against an Extracellular Peptide of the GluR3 Subtype of AMPA Receptors Activate Both Homomeric and Heteromeric AMPA Receptor Channels

Comparison of the agonist binding site o

Comparison of the agonist binding site of homomeric, heteromeric, and chimeric GluR1o and GluR3o AMPA receptors

✍ Tue G. Banke; Arne Schousboe; Darryl S. Pickering 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB

A series of AMPA [(R,S)-a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid] analogues were evaluated for activity at homomeric, heteromeric, and chimeric rat GluR1 o and GluR3 o receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique. The formation of heteromeric r