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Auto-antibody to 7,12-dimethylbenz(A)anthracene-induced leukemic cells in rats as detected by immune adherence

✍ Scribed by Takato O. Yoshida; Kuniyuki Imai; Taketoshi Sugiyama

Publisher
John Wiley and Sons
Year
1968
Tongue
French
Weight
494 KB
Volume
3
Category
Article
ISSN
0020-7136

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✦ Synopsis

Sixteen Long-Evans rats with leukemias induced by 7, Itdimethylbenz (a) anthracene were studied for evidence of naturally occurring immunologic responses to their own leukemic cells with an imn~une adherence he~iagglutinatioi? technique which was designed to detect fresh serum auto-antibodies to the membrane of the leukemic cells. Auto-antibodies to the cell membranes were found in 14 out of 16 rats, but were not demonstrable in the other two rats. Autochthonous thymus cells used as controls did not show positive immune adherence hemagglutination reactions with their own sera, nor did the leukemic cells show positive reactions with the pooled normal rat serum. These findings suggest a possibility that the leukemic rats are able to produce humoval antibodies against membrane-specific antigens of autochthonous leukemic cells.

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