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Australia — Upper limit to range of association rate constants for study : In ANAL. BIOCHEM. (235/2 (175–184) 1996) D.R. Hall, J.R. Cann & D.J. Winzor of the University of Queensland report on ‘Demonstration of an upper limit to the range of association rate constants amenable to study by biosensor technology based on surface plasmon resonance’

✍ Scribed by Valerie M. Owen

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 101 KB
Volume: 11
Category: Article
ISSN: 0956-5663
DOI: 10.1016/0956-5663(96)89464-4

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Demonstration of an Upper Limit to the R

Demonstration of an Upper Limit to the Range of Association Rate Constants Amenable to Study by Biosensor Technology Based on Surface Plasmon Resonance

✍ Damien R. Hall; John R. Cann; Donald J. Winzor 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 199 KB

Numerical simulation of BIAcore sensorgrams has highlighted the need for concern about an assumption, inherent in current determinations of rate constants for macromolecular interactions, that the concentration of solute in the flowing phase remains constant at its injected value. This assumption is