Auranofin-induced vasomotor reaction

✍ Scribed by S. M. Proudman; L. G. Cleland

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 244 KB
• Volume: 35
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780351208

✦ Synopsis

Vasomotor reactions after administration of gold sodium thiomalate (GST) are well recognized, but such reactions have not been reported to occur in association with oral gold treatment. We describe a woman with rheumatoid arthritis who experienced typical nitritoid reactions after treatment with GST, and later, with auranofin.

The nitritoid reaction is a vasomotor-like reaction which typically occurs within minutes of injection of therapeutic gold compounds. It is characterized by nausea, vomiting, facial flushing, feelings of weakness, and occasionally hypotension and syncope, presumably as a result of peripheral vasodilatation. The reaction occurs relatively infrequently and is usually associated with gdld sodium thiomalate (GST) treatment (14). Since aurothioglucose rarely causes the reaction, it can often be successfully substituted when the nitritoid reaction occurs following GST injections (5). Vasomotor reactions have not been reported to occur in conjunction with auranofin therapy.