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Augmentation of T-Cell Response with a Melanoma Cell Vaccine Expressing Specific HLA-A Antigens

✍ Scribed by D. S. B. HOON; T. MORISAKI; A. UCHIYAMA; Y. HAYASHI; L. J. FOSHAG; A. J. NIZZE; D. L. MORTON


Book ID
119869542
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
205 KB
Volume
690
Category
Article
ISSN
0890-6564

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Background. The authors have demonstrated that immunization with melanoma whole-cell vaccine (MCV) augments T-cell responses to melanoma and that cytotoxic T-cells (CTL) recognize allogeneic melanoma-bearing shared HLA-A antigens. A preclinical model was developed to assess CTL activation in vitro u