Augmentation of NK activity and/or macrophage-mediated cytotoxicity in the liver by biological response modifiers including human recombinant interleukin 2
✍ Scribed by Shu-Ren Zhang; Raoul R. Salup; Patricia E. Urias; Theresa A. Twilley; James E. Talmadge; Ronald B. Herberman; Robert H. Wiltrout
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 808 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0340-7004
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✦ Synopsis
Administration of several biological response modifiers (BRMs) to mice strongly augmented natural killer (NK) activity of leukocytes isolated from the liver. This augmentation of N K activity was induced by two synthetic molecules (MVE-2 and poly ICLC), by two BRMs of bacterial origin (formalin-fixed Propionibacterium acnes: P. acnes and a streptococcal cell wall preparation designated OK-432), as well as a single injection of human recombinant interleukin-2 (hrlL 2). All of these BRMs augmented N K activity in the liver to a greater degree than in the spleen. In addition, adherent leukocytes (>90% macrophages) isolated from the liver following P. acnes administration also exhibited augmented macrophage-mediated cytotoxicity. This cytotoxicity was characterized as macrophage mediated and distinguished from N K activity, on the basis of adherence purification, kinetics of cytotoxicity, and target cell selectivity. The results demonstrate that a variety of BRMs induce augmented natural immunity in the liver and suggest that such organ-associated immune responses may play an important role in the antimetastatic effects of BRMs.