## Abstract The levels of natural cellβmediated cytotoxicity against tumor cells in young BALB/c and BALB/c nude mice could be augmented by inoculation of a variety of mouse tumor cells or of mouse thymocytes. In older mice with low levels of spontaneous cytotoxic reactivity, inoculation of tumor c
Augmentation of natural cell-mediated cytotoxic reactivity of mouse lymphoid cells by Aloctin A
β Scribed by Ken'ichi Imanishi; Ikuo Suzuki
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 307 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0192-0561
No coin nor oath required. For personal study only.
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## Abstract Studies were performed to characterize the effector cells responsible for natural cytotoxicity of mouse lymphoid cells against a variety of syngeneic and allogeneic tumor lines. Since spleen cells from normal nude mice were found to be highly cytotoxic, they were used for most of these
## Abstract Lymphoid cells from many normal mice of a variety of inbred strains were found to have reactivity, in a ^51^Cr release cytotoxicity assay, against several syngeneic and allogeneic tumors. Very high reactivity was seen with effector cells from athymic nude mice, which was consistent with
## Abstract Treatment of rats with high doses of hydrocortisone, Xβirradiation, or cyclophosphamide had a suppressive effect on natural cytotoxicity __in vivo__. However, when rats were given poly I:C ^3^ after any of these agents, the levels of NK activity were similar to those in normal rats whic