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Augmentation as a treatment complication of restless legs syndrome: Concept and management

✍ Scribed by Diego García-Borreguero; Richard P. Allen; Heike Benes; Christopher Earley; Svenja Happe; Birgit Högl; Ralf Kohnen; Walter Paulus; David Rye; Juliane Winkelmann

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
184 KB
Volume
22
Category
Article
ISSN
0885-3185

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✦ Synopsis

Augmentation constitutes the main complication of long-term dopaminergic treatment in restless legs syndrome (RLS). Although this condition was first described in 1996, and is characterized by an overall increase in severity of RLS symptoms (including earlier onset of symptoms during the day, faster onset of symptoms when at rest, expansion to the upper limbs and trunk, and shorter duration of the treatment effect), precise diagnostic criteria were not established until 2003.

These criteria have recently been updated to form a new definition of augmentation based on multicentric studies. The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition.

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