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Atypical Processing of Amyloid Precursor Fusion Protein by Proteolytic Activity in Pichia pastoris

✍ Scribed by Adam Markaryan; Irina Morozova; Bao-Shiang Lee; Arnold Kaplan

Book ID: 115584240
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 129 KB
Volume: 262
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1999.1139

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve