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Atypical lymphocytosis in children

✍ Scribed by Gary Fleisher; Jan Paradise

Book ID
104312044
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
244 KB
Volume
10
Category
Article
ISSN
1097-6760

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✦ Synopsis

A complete blood count performed during the evaluation of a febrile or traumatized child may show the presence of atypical lymphocytosis. Although atypical lymphocytes occur in several conditions, they are most closely associated with infectious mononucleosis (IM). We initiated a study to determine if the presence in children of atypical lymphocytosis without the triad of splenomegaly, pharyngitis, and adenopathy is a manifestation of IM. Heterophil antibody (HA) and Epstein-Barr virus (EBV) titers were performed on 45 children with ~5% atypical lymphocytes. None had a significant HA titer. Thirty-three were seronegative for EBV, and 11 had titers indicative of past infection. One child had an antibody pattern suggesting a recent EBV infection; none had a titer consistent with acute IM. We conclude that isolated atypical lymphocytosis does not point to infectious mononucleosis. Fleisher G,

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