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Atypical granular cell tumor of the larynx: An unusually aggressive tumor clinically and microscopically

✍ Scribed by Dr. M. Brandwein; Drs. J. Lebenger; J. Strauchen; H. Biller

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 669 KB
Volume: 12
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880120211

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✦ Synopsis

A 36-year-old man presented with a recurrent, rapidly enlarging laryngeal tumor causing upper airway obstruction. Microscopic study revealed a granular cell tumor (GCT) with marked atypia, pleomorphism, and pagetoid spread to the overlying epithelium. Histologic pleomorphism occurs rarely and is usually mild in laryngeal GCT. Malignant granular cell tumor (MGCT), a very unusual entity, can be diagnosed with confidence when there is clinical evidence of malignancy (i.e., metastasis). We support the concept of "atypical" GCT when marked pleomorphism is present, yet no metastasis has occurred. This will indicate to the otolaryngologist and pathologist the possibility of greater potential for aggressive clinical behavior. HEAD & NECK 12~154-159,1990

Granular cell tumors (GCT) are not infrequent in the head and neck area. These tumors, while occasionally multicentric, have a low recurrence rate, even after incomplete excision.' The diagnosis of malignant granular cell tumor (MGCT) is made only rarely, usually when clinically

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