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Atypical antidopaminergic properties of CI-686: A potential antipsychotic agent

✍ Scribed by Michael Stanley; John Rotrosen; Nancy Sculerati; Samuel Gershon; Cynthia Kuhn; Bruce M. Cohen

Publisher
Springer
Year
1979
Tongue
English
Weight
459 KB
Volume
66
Category
Article
ISSN
0033-3158

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✦ Synopsis

The effects of the antipsychotic/ antidepressant drug CI-686 on apomorphine-and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

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