In Spain, despite its high rate of cadaveric donation, death while on the liver transplant waiting list is high. For this reason, living liver donation is being encouraged despite of the risk of morbidity for the donor. The objective of this study was to analyze attitudes toward living liver donation among hospital personnel in a hospital with a recently authorized living donor liver transplantation program. A random sample was taken and was stratified by type of service and job category (n ϭ 1,262). Attitude was evaluated by means of a validated psychosocial questionnaire. The questionnaire was completed anonymously and was self-administered. Statistical analysis included the Student t test, the 2 test, and logistical regression analysis. The questionnaire completion rate was 93% (n ϭ 1,168). Only 15% (n ϭ 170) of respondents were in favor of living liver donation if it were unrelated. An additional 65% (n ϭ 766) were in favor if this donation, but only for relatives. Of the rest, 9% (n ϭ 107) did not agree with living liver donation, and the remaining 11% (n ϭ 125) were undecided. The variables related to this attitude were age (P ϭ 0.044); job category (P ϭ 0.002); type of service (according to whether it is related to organ donation and transplantation) (P ϭ 0.044); participation in prosocial activities (P ϭ 0.026); attitude toward cadaveric organ donation (P Ͻ0.001); attitude of a respondent's partner toward organ donation (P ϭ 0.010); a respondent's belief that in the future, he or she may need a transplant (P Ͻ 0.001); and a willingness to receive a donated living liver organ if one were needed (P Ͻ 0.001). There is also a close relationship between attitude toward living kidney donation and living liver donation (P Ͻ 0.001). In the multivariate analysis, the only common independent variable from the bivariate analysis was a willingness to receive a living donor liver transplant if one were needed (odds ratio ϭ 9.3). Attitude toward living liver donation among hospital personnel in a hospital with a solid organ transplant program is favorable and is affected by factors related to cadaveric donation, altruistic activity, and feelings of reciprocity. Physicians and the youngest hospital workers are those who are most in favor, which leads us to think that there is a promising future for living liver transplantation, which is essential given the cadaveric organ deficit and the high mortality rate while on the waiting list.