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Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B

โœ Scribed by Alan Cheng; Noriko Uetani; Paul D. Simoncic; Vikas P. Chaubey; Ailsa Lee-Loy; C.Jane McGlade; Brian P. Kennedy; Michel L. Tremblay


Book ID
117795161
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
356 KB
Volume
2
Category
Article
ISSN
1534-5807

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Protein-Tyrosine phosphatases and the re
โœ Barry J. Goldstein ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 960 KB

Protein-tyrosine phosphatases (PTPases) play an important role in the regulation of insulin action by dephosphorylating the active (autophosphorylated) form of the insulin receptor and attenuating its tyrosine kinase activity. PTPases can also modulate post-receptor signalling by catalyzing the deph