Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation
✍ Scribed by Uri Oron; Tali Yaakobi; Amir Oron; Gal Hayam; Lior Gepstein; Ofer Rubin; Tamir Wolf; Shlomo Ben Haim
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 467 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0196-8092
- DOI
- 10.1002/lsm.1039
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Background and Objective
The aim of the present study was to investigate the possibility that low‐energy laser irradiation attenuates infarct size formation after induction of chronic myocardial infarction (MI) in small and large experimental animals.
Study Design/Materials and Methods
Laser irradiation was applied to the infarcted area of rats and dogs at various power densities (2.5 to 20 mW/cm^2^) after occlusion of the coronary artery.
Results
In infarcted laser‐irradiated rats that received laser irradiation immediately and 3 days after MI at energy densities of 2.5, 6, and 20 mW/cm^2^, there was a 14%, 62% (significant; P < 0.05), and 2.8% reduction of infarct size (14 days after MI) relative to non–laser‐irradiated rats, respectively. In dogs, a 49% (significant; P < 0.01) reduction of infarct size was achieved.
Conclusion
The results of the present study indicate that delivery of low‐energy laser irradiation to infarcted myocardium in rats and dogs has a profound effect on the infarct size after MI. Lasers Surg. Med. 28:204–211, 2001. © 2001 Wiley‐Liss, Inc.