Attenuation of anorexia induced by heat or surgery during sustained administration of ginsenoside Rg1into rat third ventricle
✍ Scribed by Kazuma Fujimoto; Toshiie Sakata; Toshiyuki Ishimaru; Hiroshi Etou; Kazuyoshi Ookuma; Mamoru Kurokawa; Hironobu Machidori
- Book ID
- 104776178
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 403 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
Effects of ginsenoside Rg~ (Rgl), a major component of panax ginseng, on modulation of ingestive behavior were investigated. No direct effect was observed on food intake after 10 gl infusion of 1.0, 2.0, 4.0 or 8.0 mM Rgl into the rat third ventricle for 10 rain. Continuous osmotic infusion of 4.0 mM Rgi at a rate of 0.966 gl/h into the third ventricle prevented feeding suppression caused by surgical procedure to implant an osmotic rain• Continuous infusion of Rgl attenuated anorexia, increased water intake, and decreased ambulation, that were produced by elevation of environmental temperature from 21~ to 30 ~ C, Consequently, rats maintained body weight and rectal temperature unchanged. The results indicate that sustained central administration of Rgt may relieve anorefia caused by implantation surgery or by a heated environment.