𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Attenuated transcriptional responses to oxidative stress in the aged rat brain

✍ Scribed by LiQi Tong; Tracy Toliver-Kinsky; Michael Edwards; David K. Rassin; Karin Werrbach-Perez; J. Regino Perez-Polo

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
219 KB
Volume
70
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The aged nervous system displays impaired cognitive functions, and these impairments are exacerbated in several neurodegenerative diseases. A role for oxidative stress has been suggested for several of these age‐associated dysfunctions. In addition, recovery from more acute traumatic insults that also generate oxidative stress is impaired in the aged. Here we examine the response of aged rat hippocampi to normobaric hyperoxia treatments and demonstrate an attenuation in the DNA binding activity of the AP‐1 and nuclear factor‐κB transcription factors, which are important components of stress response signal transduction pathways and can determine shifts in cellular commitments to necrosis, apoptosis, or functional recovery in the central nervous system. Β© 2002 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

APE/Ref-1 responses to oxidative stress
APE/Ref-1 responses to oxidative stress in aged rats
✍ Michael Edwards; David K. Rassin; Tadahide Izumi; Sankar Mitra; J. Regino Perez- πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 52 KB πŸ‘ 1 views

Chronic oxidative stress has been hypothesized to be a major contributor to the aging process. The continued exposure to reactive oxygen species (ROS) generated by oxidative metabolism or environmental sources can damage critical cellular structures and be responsible for some age-related pathology.

Responses in the aged rat brain after to
Responses in the aged rat brain after total immunolesion
✍ Zezong Gu; Juan Yu; J. Regino Perez-Polo πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 531 KB

In the present study, we compare the effects of cholinergic deafferentation of the hippocampus, cortex, and olfactory bulb of young and aged rats on nerve growth factor (NGF) protein levels in these areas. We also describe glial responses to intraventricular injections of the immunotoxin, 192 IgG-sa

Transcripts of damaged genes in the brai
Transcripts of damaged genes in the brain during cerebral oxidative stress
✍ Philip K. Liu; Tarun Arora πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 136 KB πŸ‘ 1 views

## Abstract Recent studies using ischemia/reperfusion models of brain injury suggest that there is a period of time during which the formation of oxidative DNA lesions (ODLs) exceeds removal. This interval is a window of opportunity in which to study the effect of gene damage on gene expression in

Stress-induced activation of nitric oxid
Stress-induced activation of nitric oxide-producing neurons in the rat brain
✍ Krukoff, Teresa L.; Khalili, Panteha πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 427 KB πŸ‘ 3 views

Nitric oxide (NO) is a gaseous neurotransmitter that may mediate a decrease in sympathetic output to the periphery. This implication predicts that NO-producing neurons in the brain are activated in animals experiencing increased levels of sympathetic activity. To test this prediction, we subjected t

Dysregulation of the endothelial cellula
Dysregulation of the endothelial cellular response to oxidative stress in cancer
✍ FranΓ§ois Houle; Jacques Huot πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 220 KB πŸ‘ 2 views

## Abstract The traffic of molecules and cells across the vessel wall is gated by vascular endothelial cells. In accordance, these cells play an active role in regulating cardiovascular and systemic homeostasis and in modulating physiopathological processes such as inflammation. Dysfunction of the