Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition
✍ Scribed by Rae Lynn Baldwin; Helmut Friess; Munehiro Yokoyama; Martha E. Lopez; Michael S. Kobrin; Markus W. Büchler; Murray Korc
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 724 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Transforming growth factor-6 (TGF-p) receptors constitute a family of transmembrane proteins that bind TGF-P ligands. In this study we assessed the growth responsiveness to TGF-P I in pancreatic cancer cell lines and characterized the levels of expression of TGF-f3 receptors in these cell lines and in human pancreatic cancer tissues. COLO 357 cells were most sensitive to the growth inhibitory actions of TGF-PI, PANC-I cells exhibited moderate s e m i t i i , Hs766T cells exhibited slight sensitivity and MIA PaCa-2 and T3M4 cells were resistant to TGF-PI. Only COLO 357 cells expmsed high levels of ALK5, the major type I TGF-P receptor (TPRI). Hs766T and PANC-I cells expressed high levels of SKRl, another TPRl subtype. Only MIA PaCa-2 cells did not exhibit the type II TGF-P receptor