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ATTEMPTS: A heparin/protamine-based prodrug approach for delivery of thrombolytic drugs

โœ Scribed by Jun Feng Liang; Yoon Jeong Park; Hui Song; Yong Tao Li; Victor Chi-Min Yang

Book ID
114160845
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
509 KB
Volume
72
Category
Article
ISSN
0168-3659

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A novel heparin/protamine-based pro-drug
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โœ Jun Feng Liang; Hui Song; Yong Tao Li; Victor C. Yang ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 414 KB ๐Ÿ‘ 1 views

Previously we proposed a heparin/protamine-based system for delivery of protease drugs such as tissue-specific plasminogen activator (tPA). To demonstrate the feasibility of this approach as well as its pro-drug and triggered release features, positively charged peptides [(Arg) 7 Cys] were successfu