Atropurpuran, a novel diterpene with an unprecedented pentacyclic cage skeleton, from Aconitum hemsleyanum var. atropurpureum

✍ Scribed by Pei Tang; Qiao-Hong Chen; Feng-Peng Wang

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 226 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.11.028

✦ Synopsis

A novel diterpene with an unprecedented pentacyclic skeleton, designated as atropurpuran (1), featuring a unique motif to fuse two bicyclo[2.2.2]octane units, was isolated from the roots of Aconitum hemsleyanum var. atropurpureum. Its structure and relative configuration were established by NMR techniques and single-crystal X-ray diffraction. The biosynthetic origin of 1 was proposed to be Hetidane-type diterpenoid.