Atrophy of the corpus callosum, cognitive impairment, and cortical hypometabolism in progressive supranuclear palsy
β Scribed by Hiroshi Yamauchi; Dr Hidenao Fukuyama; Yasuhiro Nagahama; Yukinori Katsumi; Yun Dong; Junji Konishi; Jun Kimura
- Book ID
- 118281424
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 1012 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Abnormalities in energy metabolism and oxidative stress accompany many neurodegenerative diseases, including progressive supranuclear palsy (PSP). Previously, we showed decreased activities of a mitochondrial enzyme complex, Ξ±βketoglutarate dehydrogenase complex (KGDHC), and marked incr
The topographic distribution of brain atrophy was quantified by image analysis of fixed coronal brain slices from 12 patients dying with Huntington's disease (HD) and from 4 other patients dying with progressive supranuclear palsy (PSP). In HD, atrophy was maximal within the caudate nucleus, putamen