Atrial natriuretic peptide and endothelin: modulators of renal function
β Scribed by Kramer, H. J. ;Backer, A. ;Bokemeyer, D. ;Meyer-Lehnert, H.
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 311 KB
- Volume
- 72
- Category
- Article
- ISSN
- 1432-1440
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Atrial Natriuretic Peptide (ANP) and receptors for ANP are widely distributed in many tissues and cell types in vertebrates. ANP has been shown to be internalized into the cytoplasm in several cell types and thus it raises the possibility that it may act on intracellular receptors. Displacement expe
## Abstract Upβregulation of atrial natriuretic peptide (ANP) mRNA in the kidneys in several disorders has been demonstrated; however, evidence that ANP synthesized by the kidney exerts a local function has never been produced. Therefore, we investigated whether endogenous ANP could modulate high g