Atrial natriuretic factor-receptor guanylate cyclase signal transduction mechanism
โ Scribed by Teresa Duda
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 509 KB
- Volume
- 334
- Category
- Article
- ISSN
- 0300-8177
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Original studies with rat adrenocortical carcinoma identified a 180 kDa cell-surface protein which contained both guanylate cyclase and atrial natriuretic factor (ANF) receptor, representing a potentially new type of bifunctional receptor protein. It is both a receptor and a guanylate cyclase. This
The putative 'second messenger' of certain atrial natriuretic factor (ANF) signal transductions is cyclic GMP. Recently, we purified a 180-kDa protein, apparently containing both ANF receptor and guanylate cyclase activities, and hypothesized that this is one of the cyclic GMP transmembrane signal t