✦ LIBER ✦

Atrial natriuretic factor inhibits mitogen-induced growth in aortic smooth muscle cells

✍ Scribed by P.M. Baldini; P. De Vito; M. Fraziano; P. Mattioli; P. Luly; P. Di Nardo

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 188 KB
Volume: 193
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.10155

No coin nor oath required. For personal study only.

✦ Synopsis

Atrial natriuretic factor (ANF) is a polypeptide able to affect cardiovascular homeostasis exhibiting diuretic, natriuretic, and vasorelaxant activities. ANF shows antimitogenic effects in different cell types acting through R(2) receptor. Excessive proliferation of smooth muscle cells is a common phenomenon in diseases such as atherosclerosis, but the role of growth factors in the mechanism which modulate this process has yet to be clarified. The potential antimitogenic role of ANF on the cell growth induced by growth factors appears very intriguing. Aim of the present study was to investigate the possible involvement of ANF on rat aortic smooth muscle (RASM) cells proliferation induced by known mitogens and the mechanism involved. Our data show that ANF, at physiological concentration range, inhibits RASM cell proliferation induced by known mitogens such as PDGF and insulin, and the effect seems to be elicited through the modulation of phosphatidic acid (PA) production and MAP kinases involvement.

📜 SIMILAR VOLUMES

Basic fibroblast growth factor decreases

Basic fibroblast growth factor decreases elastin gene transcription in aortic smooth muscle cells

✍ Isabel Carreras; Celeste B. Rich; Mikhail P. Panchenko; Judith Ann Foster 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

## Abstract The extracellular matrix (ECM) protein elastin plays an essential role in the cardiovascular system by imparting elasticity to blood vessel wall. In this study, we examined the effect of basic fibroblast growth factor (bFGF) on the expression of elastin in aortic smooth muscle cells (SM

Phosphatidylinositol- and phosphatidylch

Phosphatidylinositol- and phosphatidylcholine-dependent phospholipases C are involved in the mechanism of action of atrial natriuretic factor in cultured rat aortic smooth muscle cells

✍ Antonella Zannetti; Paolo Luly; Roberto Musanti; Patrizia M. Baldini 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB 👁 2 views

We have investigated the involvement of specific phospholipase systems and their possible mutual relationship with the mechanism by which atrial natriuretic factor (ANF) increases phosphatidate (PA) and diacylglycerol (DAG) in rat aortic smooth muscle cells (RASMC), one of the major targets of this

Basic fibroblast growth factor decreases

Basic fibroblast growth factor decreases type V/XI collagen expression in cultured bovine aortic smooth muscle cells

✍ Kyriakos E. Kypreos; Gail E. Sonenshein 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 1 views

Vascular smooth muscle cells (SMCs), the major cellular constituent of an artery, synthesize the bulk of fibrillar collagens, including type V/XI, which regulates heterotypic collagen fibril assembly. Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide growth factor that has been

Insulin-like growth factor-1 increases e

Insulin-like growth factor-1 increases endothelin receptor A levels and action in cultured rat aortic smooth muscle cells

✍ Ching Fai Kwok; Chi-Chang Juan; Kuang-Chung Shih; Chii-Min Hwu; Tjin-Shing Jap; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 176 KB

## Abstract Insulin is known to cause an increase in endothelin‐1 (ET‐1) receptors in vascular smooth muscle cells (SMCs), but the effect of insulin‐like growth factor 1 (IGF‐1) on ET‐1 receptor expression is not known. We therefore carried out the present study to determine the effect of IGF‐1 on

Naringin inhibits matrix metalloproteina

Naringin inhibits matrix metalloproteinase-9 expression and AKT phosphorylation in tumor necrosis factor-α-induced vascular smooth muscle cells

✍ Eo-Jin Lee; Dong-Il Kim; Wun-Jae Kim; Sung-Kwon Moon 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 307 KB

Citrus fruits are high in naringin, which has a beneficial effect on cardiovascular diseases. However, the matrix metalloproteinase-9 (MMP-9) regulation involved in cell migration and invasion remains to be identified. Naringin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of

Involvement of S6 kinase and p38 mitogen

Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cells

✍ Wei Li; Quanhai Chen; Ira Mills; Bauer E. Sumpio 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 2 views

## Abstract Bovine aortic smooth muscle cell (SMC) phenotype can be altered by physical forces. This has been demonstrated by cyclic strain‐induced changes in proliferation and alignment. However, the intracellular coupling pathways remain ill defined. In the present study, we examined whether the