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ATP7B Mediates Vesicular Sequestration of Copper: Insight Into Biliary Copper Excretion

✍ Scribed by Michael A. Cater; Sharon La Fontaine; Kristy Shield; Yolanda Deal; Julian F.B. Mercer

Book ID
119758934
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
620 KB
Volume
130
Category
Article
ISSN
0016-5085

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Copper toxicosis can occur in the absence of biliary copper excretion. To demonstrate whether biliary copper excretion capacity is correlated with hepatic mass and ATP7B function, we undertook studies in intact animals. Copper-histidine was injected intrasplenically after baseline bile collection, f