✦ LIBER ✦

ATP-Sensitive K+ channels mediate an IPSP in dorsal horn neurones elicited by sensory stimulation

✍ Scribed by Michael W. Salter; Yves De Koninck; James L. Henry

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 758 KB
Volume: 11
Category: Article
ISSN: 0887-4476
DOI: 10.1002/syn.890110306

No coin nor oath required. For personal study only.

✦ Synopsis

Nociceptive dorsal horn neurones, which are involved in the processing of pain-related information, are inhibited by input from vibration-sensitive, large diameter primary sensory fibres (Wall and Cronly-Dillon, 1960; Salter and Henry, 1990a,b). We have reported previously that the inhibition of spinal nociceptive neurones by vibration is mediated by adenosine acting through PI-purinergic receptors (Salter and Henry, 1987). In a number of different types of cell, adenosine is known t o activate K+ currents (Gerber et al.

📜 SIMILAR VOLUMES

An inhibitory postsynaptic potential in

An inhibitory postsynaptic potential in spinal nociceptive neurones is mediated by adenosine through activation of ATP-sensitive K+ channels

✍ Michael W. Salter; Yves De Koninck; James L. Henry 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 682 KB

Inhibitory processes within the dorsal horn participate in regulating the transmission of nociceptive information. Spinal nociceptive neurones are inhibited by cutaneously applied vibration and we have characterized this inhibition physiologically and pharmacologically [Salter et al., 19931. This in